Nanoparticle of Telmisartan and Polyvinylpyrrolidone K-30: Characterization and Dissolution Study

Background: Telmisartan (TEL) is an orally active nonpeptide angiotensin II antagonist drug. The drug acts on a subtype of AT1 receptors, which serves to cope with high blood pressure (hypertension). TEL class Biopharmaceutical Classification System (BCS), that has low solubility in water and permeability. Objectives: This study aims determine the effect formation TEL-PVP K-30 nanoparticles through solvent drop grinding method characteristics physicochemical properties rate dissolution TEL. Methods: Nanoparticles are made 2 formulas, namely formula 1: 1 2. Results: Characterization Particle Size Analyzer (PSA) was performed results 1:1 24nm, 1:2 35nm. X-ray Diffraction (XRD) analysis resulted from decrease intensity crystallinity degrees. Fourier Transform Infrared (FT-IR) Spectroscopy occurs wave number shift. Differential Scanning Calorimetry (DSC) decreases melting point. carried out using pH 7.5 phosphate tart medium. Conclusion: result increased by 3.3 times for 2.9 1:2.
 Keywords: Telmisartan; polyvinylpyrrolidone K-30; nanoparticles; grinding.